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IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases - Nature Biotechnology

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IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases - Nature Biotechnology

The success of chimeric antigen receptor (CAR) T cell therapy in treating several hematopoietic malignancies has been difficult to replicate in solid tumors, in part because of T cell exhaustion and eventually dysfunction. To counter T cell dysfunction in the tumor microenvironment, we metabolically armored CAR T cells by engineering them to secrete interleukin-10 (IL-10).

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IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases - Nature Biotechnology

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IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases - Nature Biotechnology

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