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Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease - Nature Cancer

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Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease - Nature Cancer

Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance, the mechanisms underlying the behavior and therapeutic response of this disease are poorly understood owing, in part, to a paucity of tractable models. Here we developed methods to somatically introduce different oncogenic lesions directly into the murine gastric epithelium.

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Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease - Nature Cancer

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Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease - Nature Cancer

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