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Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers - Nature Cancer

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Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers - Nature Cancer

Mutations in human cells exhibit increased burden in heterochromatic, late DNA replication time (RT) chromosomal domains, with variation in mutation rates between tissues mirroring variation in heterochromatin and RT. We observed that regional mutation risk further varies between individual tumors in a manner independent of cell type, identifying three signatures of domain-scale mutagenesis in >4,000 tumor genomes.

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Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers - Nature Cancer

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Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers - Nature Cancer

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