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Trpv4-mediated apoptosis of Leydig cells induced by high temperature regulates sperm development and motility in zebrafish - Communications Biology

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Trpv4-mediated apoptosis of Leydig cells induced by high temperature regulates sperm development and motility in zebrafish - Communications Biology

Exposure of testes to high-temperature environment results in defective spermatogenesis. Zebrafish exposed to high temperature exhibited apoptosis not only in germ cells but also in Leydig cells, as expected from studies using mice or salmon. However, the role of testicular somatic cells in spermatogenesis defects remains unclear. We found that in Leydig cells the Trpv4 gene encoding the temperature sensitive ion channel was specifically upregulated in high temperature.

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Trpv4-mediated apoptosis of Leydig cells induced by high temperature regulates sperm development and motility in zebrafish - Communications Biology

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Trpv4-mediated apoptosis of Leydig cells induced by high temperature regulates sperm development and motility in zebrafish - Communications Biology

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