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An error correction strategy for image reconstruction by DNA sequencing microscopy - Nature Computational Science

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An error correction strategy for image reconstruction by DNA sequencing microscopy - Nature Computational Science

By pairing adjacent molecules in situ and then mapping these pairs, DNA microscopy could substantially reduce the workload in spatial omics methods by directly inferring geometry from sequencing data alone. However, experimental artifacts can lead to errors in the adjacency data, which distort the spatial reconstruction. Here we describe a method to correct two such errors: spurious crosslinks formed between any two nodes, and fused nodes that are formed out of multiple molecules.

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An error correction strategy for image reconstruction by DNA sequencing microscopy - Nature Computational Science

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An error correction strategy for image reconstruction by DNA sequencing microscopy - Nature Computational Science

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