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DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation - Nature Structural & Molecular Biology

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DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation - Nature Structural & Molecular Biology

As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation levels. During this transition, the germline is specified and undergoes genome-wide DNA demethylation, while emergence of the three somatic germ layers is preceded by acquisition of somatic DNA methylation levels in the primed epiblast.

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DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation - Nature Structural & Molecular Biology

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DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation - Nature Structural & Molecular Biology

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