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A RalA between high-fat diet and mitochondrial shape - Nature Metabolism

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A RalA between high-fat diet and mitochondrial shape - Nature Metabolism

High-fat diet (HFD) causes mitochondrial dysfunction in white adipocytes. A study in Nature Metabolism identifies the small GTPase RalA as a culprit in mice. Upon HFD, RalA activates the fission protein Drp1 to cause mitochondrial fragmentation and dysfunction, linking mitochondrial fuel utilization in white adipocytes to systemic lipid metabolism.

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A RalA between high-fat diet and mitochondrial shape - Nature Metabolism

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A RalA between high-fat diet and mitochondrial shape - Nature Metabolism

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