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Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results - Nature Medicine
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Compromised vascular endothelial barrier function is a salient feature of diabetic complications such as sight-threatening diabetic macular edema (DME). Current standards of care for DME manage aspects of the disease, but require frequent intravitreal administration and are poorly effective in large subsets of patients.
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