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Simultaneous nanopore profiling of mRNA m6A and pseudouridine reveals translation coordination - Nature Biotechnology

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Simultaneous nanopore profiling of mRNA m6A and pseudouridine reveals translation coordination - Nature Biotechnology

N6-methyladenosine (m6A) and pseudouridine (Ψ) are the two most abundant modifications in mammalian messenger RNA, but the coordination of their biological functions remains poorly understood. We develop a machine learning-based nanopore direct RNA sequencing method (NanoSPA) that simultaneously analyzes m6A and Ψ in the human transcriptome.

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Simultaneous nanopore profiling of mRNA m6A and pseudouridine reveals translation coordination - Nature Biotechnology

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Simultaneous nanopore profiling of mRNA m6A and pseudouridine reveals translation coordination - Nature Biotechnology

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