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Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis - Nature Metabolism

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Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis - Nature Metabolism

Skeletal muscle is dynamically controlled by the balance of protein synthesis and degradation. Here we discover an unexpected function for the transcriptional repressor B cell lymphoma 6 (BCL6) in muscle proteostasis and strength in mice. Skeletal muscle-specific Bcl6 ablation in utero or in adult mice results in over 30% decreased muscle mass and force production due to reduced protein synthesis and increased autophagy, while it promotes a shift to a slower myosin heavy chain fibre profile.

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Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis - Nature Metabolism

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Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis - Nature Metabolism

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