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Chemical rewiring of ubiquitination by degraders and their selectivity routes - Nature Structural & Molecular Biology

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Chemical rewiring of ubiquitination by degraders and their selectivity routes - Nature Structural & Molecular Biology

Ubiquitination is an essential process that curtails cellular levels of damaged and redundant proteins. Chemical biologists have harnessed this natural system to induce the degradation of disease-relevant proteins. We reflect here on the potential of 'degraders' for targeted selectivity, and discuss the role of computer-aided drug design in shaping future advances.

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Chemical rewiring of ubiquitination by degraders and their selectivity routes - Nature Structural & Molecular Biology

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Chemical rewiring of ubiquitination by degraders and their selectivity routes - Nature Structural & Molecular Biology

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