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ATX restricts anti-tumor eosinophil responses - Nature Cancer

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ATX restricts anti-tumor eosinophil responses - Nature Cancer

Autotaxin (ATX) produces lysophosphatidic acid (LPA), which directly promotes pancreatic ductal adenocarcinoma (PDAC) growth, but the role of the tumor microenvironment (TME) in ATX-driven tumor growth is unclear. ATX–LPA signaling in PDAC is now shown to shape the TME by inhibiting eosinophil recruitment, resulting in increased tumor growth.

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ATX restricts anti-tumor eosinophil responses - Nature Cancer

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