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Structural basis of human U5 snRNP late biogenesis and recycling - Nature Structural & Molecular Biology

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Structural basis of human U5 snRNP late biogenesis and recycling - Nature Structural & Molecular Biology

Pre-mRNA splicing by the spliceosome requires the biogenesis and recycling of its small nuclear ribonucleoprotein (snRNP) complexes, which are consumed in each round of splicing. The human U5 snRNP is the ~1 MDa 'heart' of the spliceosome and is recycled through an unknown mechanism involving major architectural rearrangements and the dedicated chaperones CD2BP2 and TSSC4. Late steps in U5 snRNP biogenesis similarly involve these chaperones.

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Structural basis of human U5 snRNP late biogenesis and recycling - Nature Structural & Molecular Biology

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Structural basis of human U5 snRNP late biogenesis and recycling - Nature Structural & Molecular Biology

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