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Cancer-derived exosomal Alu RNA promotes colorectal cancer progression - Experimental & Molecular Medicine

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Cancer-derived exosomal Alu RNA promotes colorectal cancer progression - Experimental & Molecular Medicine

Inflammation plays a crucial role in cancer progression, but the relevance of the inflammasome remains unclear. Alu RNA was the first endogenous nucleic acid shown to activate the NLRP3 (nucleotide-binding domain leucine-rich repeat containing 3) inflammasome. Here, we showed that Alu RNA can induce epithelial-to-mesenchymal transition (EMT) through NLRP3 inflammasome activation and IL-1β release in colorectal cancer (CRC) cells.

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Cancer-derived exosomal Alu RNA promotes colorectal cancer progression - Experimental & Molecular Medicine

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Cancer-derived exosomal Alu RNA promotes colorectal cancer progression - Experimental & Molecular Medicine

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