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Segregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development - Communications Biology

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Segregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development - Communications Biology

Shox2 plays a vital role in the morphogenesis and physiological function of the sinoatrial node (SAN), the primary cardiac pacemaker, manifested by the formation of a hypoplastic SAN and failed differentiation of pacemaker cells in Shox2 mutants. Shox2 and Nkx2-5 are co-expressed in the developing SAN and regulate the fate of the pacemaker cells through a Shox2-Nkx2-5 antagonistic mechanism.

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Segregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development - Communications Biology

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Segregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development - Communications Biology

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