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RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation - Cell Death & Differentiation

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RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation - Cell Death & Differentiation

Caspase-8 activity is required to inhibit necroptosis during embryogenesis in mice. In vitro studies have suggested that caspase-8 directly cleaves RIPK1, CYLD and the key necroptotic effector kinase RIPK3 to repress necroptosis. However, recent studies have shown that mice expressing uncleavable RIPK1 die during embryogenesis due to excessive apoptosis, while uncleavable CYLD mice are viable. Therefore, these results raise important questions about the role of RIPK3 cleavage.

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RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation - Cell Death & Differentiation

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RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation - Cell Death & Differentiation

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