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PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma - Oncogenesis

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PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma - Oncogenesis

Protein kinase C (PKC) is activated downstream of gain-of-function GNAQ or GNA11 (GNAQ/GNA11) mutations in over 90% of uveal melanoma (UM). Phase I clinical trials of PKC inhibitors have shown modest response rates with no survival benefit in metastatic UM. Although PKC inhibitors actively suppress mitogen-activated protein kinase (MAPK) signalling in UM, the effect on other UM signalling cascades is not well understood.

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PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma - Oncogenesis

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PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma - Oncogenesis

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